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. 2015 Mar 30;107(1):108–118. doi: 10.1093/cvr/cvv122

Figure 6.

Figure 6

Effects of chronic hypoxia (10% O2 for 21 days) on BMP4 mRNA and protein expression in distal PA from HIF-1α+/+ and HIF-1α+/− mice. (A) Levels of BMP4 mRNA determined by real-time PCR in distal PA from CH-exposed HIF-1α+/+ and HIF-1α+/− mice were normalized to CpB and presented as percentage of respective Nor control. Values are mean ± SEM, n = 5 for each group of animals, *P < 0.05. (B) Representative western blots of BMP4 proteins and actin in distal PA from Nor or CH-exposed HIF-1α+/+ and HIF-1α+/− mice. (C) Intensity changes of BMP4 pro- and mature protein expression normalized to actin. Values are mean ± SEM, n = 5 for each group of animals, *P < 0.05.