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. 2015 Apr 16;24(14):3971–3981. doi: 10.1093/hmg/ddv135

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Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US

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Figure 3. — Active Hsc70 can only promote MT bundling in neurons when tau is present. Microtubule thickness in WT or Mapt^−/− organotypic hippocampal slices expressing AAV9-GFP, WT Hsc70-Flag or inactive Hsc70-Flag immunostained with anti-acetylated-tubulin. Scale bar is 10 µm (×60). Thickness data are mean diameter ± SEM, n = 4 animals, three slices per animal by one-way ANOVA (P = < 0.0001, F = 40.14; ***P < 0.001 by Tukey's post-hoc analysis). Results from inactive Hsc70 transduced slices are not shown because no acetylated-tubulin signal was visible.