Figure 6.

Intermittent treatment with an Hsp70 inhibitor does not impair MT integrity. (A) Acetylated tubulin in tau transgenic mice organotypic slices treated chronically or intermittently with 1 µm JG-98. Quantification of bundled tubulin ± SEM, n = 10, by one-way ANOVA (P = 0.0012, F = 10.47, *P < 0.05, with Tukey's post-hoc test for multiple comparisons). Scale bar is 10 µm at ×60. (B) Schematic representation illustrating that Hsc70 ATPase activity, with tau, is required for proper MT dynamics.