Characterization of gene features used in the integrative regression model. (A) Number of CD-associated region genes that are highly expressed in LPMC (n = 6), terminal ileal biopsies (n = 58), body tissues (one sample from each of 16 tissues) and brain (n = 5). The number of CD region genes highly expressed is significantly higher in the intestine tissues (LPMC and terminal ileum) than in other body tissues (Wilcoxon's test P-value = 3E−8). Among the body tissues, the number of CD region genes which are highly expressed is highest in white blood cells (red triangle) and lowest in the brain. (B) Pairwise correlation among gene features in the model. AI, autoimmune diseases; DEX, differentially expressed; PB, peripheral blood.