Fig. 3.

Dose-dependent inhibition of tumor growth by RAD1901 in an MCF-7 mouse xenograft model. Female nude mice were implanted with 1×10⁷ MCF-7 cells subcutaneously in the right flank. Fourteen days after implantation, tumor volumes were recorded and treatment was initiated with vehicle, tamoxifen (1 mg/animal every other day), fulvestrant (0.5 mg/animal daily), or RAD1901 (0.3, 1, 3, 10, 30, 60, 90, and 120 mg/kg daily). Tumor volume was evaluated twice per week until the study endpoint. (a) Mean tumor volumes over time for daily doses of 0.3, 1, 3, 10, 30, 60 mg/kg RAD1901, tamoxifen, and fulvestrant. (b) Box and whisker plots show the day 40 tumor volume by group. The box represents the 25th through 75th percentiles of observations, the line represents the mean of the observations, and the whiskers represent the extreme observations. (c) Mean tumor volumes over time for daily doses of 60, 90, and 120 mg/kg RAD1901, tamoxifen, and fulvestrant. (d) Tumor volumes from individual animals at day 42, with the mean percent change detailed for each group.