TABLE 2.
Nonredundant gene modules involved in nutrient derivation from extracellular uptake or de novo biosynthesis
| Nutrient/energy factor(s) | Coding gene(s)a | Functional classification | KEGG pathway/module |
|---|---|---|---|
| Biotin | 1341 | Biotin utilization | Biotin transport system |
| Heme iron | 1168:1177 | Heme iron uptake | Heme iron utilization |
| Mn2+ | 1517:1519 | Mn2+ transport | Mn2+/iron transport system |
| Dipeptide | 1707:1711 | Dipeptide transport | Dipeptide transport system |
| Oligopeptide | 1266:1270 | Oligopeptide transport | Oligopeptide transport system |
| Amino acids (Met) | 1616:1619 | Amino acid transport (Met) | Met transport system |
| Amino acids (Gln) | 1240:1241 | Gln biosynthesis/nitrogen metabolism | Gln biosynthesis |
| Fatty acids | 1132:1144 | Fatty acid biosynthesis | Fatty acid biosynthesis FASII |
| Isoprenoid | 0361:0366; 1042; 1387; 1461 | Fatty acid biosynthesis (isoprenoid) | Terpenoid biosynthesis |
| Aminoacyl-tRNA (Pro) | 1679 | tRNA charging (Pro) | tRNA charging (Pro) |
| Aminoacyl-tRNA (Tyr) | 0077 | tRNA charging (Tyr) | tRNA charging (Tyr) |
| Aminoacyl-tRNA (Arg) | 1813:1814 | tRNA charging (Arg) | tRNA charging (Arg) |
| Aminoacyl-tRNA (Trp) | 1764 | tRNA charging (Trp) | tRNA charging (Trp) |
| Aminoacyl-tRNA (Leu) | 1359 | tRNA charging (Leu) | tRNA charging (Leu) |
| Energy metabolism | 0804:0808; 1547; 0767; 0525; 0656:0657 | Energy metabolism | Pyruvate metabolism |
| Energy production | 0253:0260 | Energy production | Oxidative phosphorylation |
a
Numbers correspond to the gene identifier(s) (ID) annotated in the genome of S. pyogenes M23ND.