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. Author manuscript; available in PMC: 2015 Sep 4.
Published in final edited form as: Proteomics Clin Appl. 2014 Aug;8(0):534–542. doi: 10.1002/prca.201400037

Table 1.

Examples of known cleaved amyloid-forming precursors.

Protein Function/Disease
Pmel17 Melanosome biogenesis (physiological)
Lithostathine AD, pancreatic stones
Gelsolin (Asp 187 to Asn or Tyr) Familial Amyloidosis Finnish type (FAF)
Cystatin C (Leu 68 to Gln) Hereditary Cystatin C Amyloid Angiopathy (HCCAA)
ApoAIV/TTR Cardiac Amyloidosis
ApoAI Atherosclerothic plaques, and Familial Amyloid Polyneuropathy (FAP) Type III
ApoSAA AA amyloid fibrils
α/β tubulin/BRI Familial British (FBD) and Danish dementia
Β2Microglobulin Long-term dialysis
TTR Familial Amyloid Polyneuropathy (FAP) and senile systematic amyloidosis (SSA)
α-synuclein Parkinson’s, Dementia with Lewy Bodies (DLB), AD, Multiple System Atrophy (MSA) and Amyotrophic Lateral Sclerosis (ALS)
Aβ AD
PrPc Creutzfeldt-Jakob
Huntingtin Hungtinton’s
Glycoprotein B HSV1/AD

Adapted with permission from[19]