Table 3. Chest imaging characteristics, lung function, sputum bacteriology, sputum inflammatory biomarkers and cough sensitivity.
| Parameters | CRS | No CRS | P value |
|---|---|---|---|
| No. of patients | 47 | 101 | - |
| No. of bronchiectatic lobes | 4.0 (3.0) | 4.0 (3.0) | 0.28 |
| HRCT total score | 7.0 (7.0) | 7.0 (5.0) | 0.46 |
| Cystic bronchiectasis (No., %) | 20 (42.6%) | 62 (61.4%) | 0.03 |
| Predominantly middle/lower lobe bronchiectasis (No., %) | 36 (76.6%) | 69 (68.3%) | 0.30 |
| Pulmonary emphysema (No., %) | 9 (19.1%) | 18 (17.8%) | 0.85 |
| Dyshomogeneity (No., %) | 31 (66.0%) | 63 (62.4%) | 0.67 |
| Atelectasis (No., %) | 12 (25.5%) | 28 (27.8%) | 0.78 |
| Cavity (No., %) | 18 (38.3%) | 44 (43.6%) | 0.55 |
| Pulmonary infiltration (No., %) | 41 (87.2%) | 93 (92.1%) | 0.35 |
| Bilateral bronchiectasis (No., %) | 40 (85.1%) | 81 (80.2%) | 0.47 |
| Lung function | - | - | - |
| FVC% predicted | 78.2±19.8 | 82.2 (16.8) | 0.54 |
| FEV 1 % predicted | 68.2±24.8 | 74.8 (21.2) | 0.29 |
| FEV 1 /FVC% | 75.3 (19.6) | 73.8±12.7 | 0.28 |
| MMEF% predicted | 51.2±29.3 | 59.2±31.0 | 0.14 |
| D L CO% predicted | 89.7±14.1 | 89.0±19.9 | 0.84 |
| Baseline sputum bacteriology (No., %) | - | - | 0.27 |
| Pseudomonas aeruginosa | 17 (36.2%) | 27 (26.7%) | - |
| Other potentially pathogenic microorganisms * | 15 (31.9%) | 28 (27.7%) | - |
| Commensals | 15 (31.9%) | 46 (45.5%) | - |
| Sputum bacterial colonization (No.,%) | - | - | 0.12 |
| Pseudomonas aeruginosa | 17 (36.2%) | 22 (21.8%) | - |
| Other potentially pathogenic microorganisms * | 4 (8.5%) | 6 (5.9%) | - |
| None | 26 (55.3%) | 73 (72.3%) | - |
| Sputum inflammatory biomarkers | - | - | - |
| Sputum IL-1β (ng/ml) ** | 18.6 | 19.7 | 0.85 |
| Sputum TNF-α (ng/ml) ** | 10.3 | 8.3 | 0.30 |
| Sputum IL-6 (ng/ml) ** | 2.6 | 2.0 | 0.14 |
| Sputum IL-8 (ng/ml) ** | 117.3 | 110.4 | 0.52 |
| Capsaicin cough sensitivity | - | - | - |
| C2 (μmol/L) | 3.9 (123.0) | 11.7 (123.0) | 0.81 |
| C5 (μmol/L) | 62.5 (996.0) | 250.0 (973.0) | 0.32 |
Numerical data were presented as mean ± standard deviation for normal distribution or otherwise median (interquartile range). Categorical data were expressed as number (percentage).
Data in bold indicated the comparisons with statistical significance.
* Other potentially pathogenic microorganisms included Haemophilus influenzae, Haemophilus parainfluenzae, Staphylococcus aureus, Stenotrophomonas maltophilia, Escherichia colitis, Sphingomonas paucimobilis, Alcaligenes faecalis subsp faecalis, Psedumonas pseudoalcaligenes and Serratia marcescens.
** Data were presented as geometric means.
IL: interleukin; TNF: tumor necrosis factor