Table 3. Results of the structural and functional ALE-meta analyses and conjunction analysis of structure and functional alterations in adolescents with AB.
| Region | BA | H | Volume | Local Maxima | |||
| Structural Meta-Analysis (TD>AB) | |||||||
| 1 | inferior frontal/precentral gyrus, | 13, | R | 1952 | 54 | 16 | 10 |
| insula | 44, 45 | 62 | 20 | 6 | |||
| 56 | 26 | 16 | |||||
| 2 | subcallosal gyrus, putamen, | 34 | R | 1672 | 26 | 4 | -16 |
| lateral globus pallidus, amygdala | 22 | 4 | -8 | ||||
| 14 | 10 | -12 | |||||
| 3 | inferior frontal gyrus | 45, 47 | R | 1304 | 52 | 26 | -10 |
| 4 | insula | 13 | L | 1144 | -38 | 8 | 8 |
| -38 | 4 | -2 | |||||
| 5 | middle/superior frontal gyrus | 9,8 | R | 1112 | 34 | 48 | 30 |
| 40 | 38 | 30 | |||||
| 6 | middle/inferior frontal gyrus | 10,46 | L | 1040 | -36 | 48 | -2 |
| -46 | 48 | 2 | |||||
| 7 | putamen, claustrum | R | 688 | 34 | 2 | -2 | |
| 8 | thalamus | R | 560 | 20 | -30 | 8 | |
| 9 | subcallosal/middle frontal gyrus, cingulate | 25 | R | 528 | 10 | 14 | -22 |
| 10 | cingulate/middle frontal gyrus | 32 | L | 528 | -10 | 24 | 42 |
| 11 | claustrum | L | 520 | -24 | 20 | 8 | |
| 12 | claustrum, insula | R | 520 | 32 | 14 | 10 | |
| 13 | subcallosal/parahippocampal gyrus, amygdala | 34 | L | 512 | -30 | 4 | -18 |
| 14 | culmen, declive | R | 512 | 4 | -58 | -16 | |
| 15 | caudate | R | 512 | 10 | 14 | 2 | |
| 16 | thalamus | L | 512 | -8 | -16 | 15 | |
| 17 | inferior frontal gyrus | 47 | R | 504 | 46 | 26 | -30 |
| 18 | middle temporal gyrus | 37 | R | 504 | 54 | -68 | 12 |
| 19 | superior frontal gyrus | 9 | R | 504 | 18 | 56 | 20 |
| All x, y, z-coordinates represent local maxima in MNI space | AB=Aggressive Behaviour | ||||||
| Volume=Volume (mm3) | TD=Typically developing controls | ||||||
| H=Hemisphere | BA= Brodmann areas | ||||||
| R=Right; L=Left | |||||||
| Region | BA | H | Volume | Local Maxima | |||
| Functional Meta-Analysis (TD>AB) | |||||||
| 1 | middle/superior frontal gyrus, | 8, 9, | R/L | 3728 | 14 | 44 | 30 |
| anterior cingulate gyrus | 10, 32 | 8 | 36 | 28 | |||
| 22 | 48 | 22 | |||||
| 32 | 50 | 14 | |||||
| 0 | 36 | 24 | |||||
| 2 | thalamus, lentiform nucleus, | L | 1944 | -6 | -12 | -4 | |
| putamen, medial globus pallidus | -26 | -8 | -12 | ||||
| amygdala | -16 | -8 | -4 | ||||
| 3 | claustrum, insula | 13 | L | 1896 | -28 | 20 | 0 |
| -38 | 20 | 12 | |||||
| 4 | middle frontal gyrus, | 11, 24 | R | 1328 | 12 | 30 | -20 |
| anterior cingulate | 4 | 30 | -14 | ||||
| 5 | inferior/middle temporal gyrus | 21 | L | 1288 | -48 | -8 | -26 |
| 6 | amygdala, parahippocampal | 28 | R | 1224 | 30 | -4 | -28 |
| gyrus | 20 | -2 | -30 | ||||
| 7 | claustrum, putamen, insula | 13 | R | 776 | 28 | 20 | 0 |
| 30 | 24 | -2 | |||||
| 8 | superior, middle frontal gyrus | 9 | R | 552 | 14 | 60 | 16 |
| Conjunction: Structural (TD>AB) ∩ Functional (TD>AB) | |||||||
| 1 | superior frontal gyrus (dmPFC) | 9 | R | 128 | 16 | 58 | 18 |
| 2 | claustrum, insula | L | 8 | -26 | 20 | 4 | |
| 3 | claustrum, insula | L | 8 | -28 | 18 | 6 | |
All x, y, z-coordinates represent local maxima in MNI space. AB = Aggressive Behaviour. Volume = Volume (mm3). TD = Typically developing controls. H = Hemisphere. BA = Brodmann areas. R = Right; L = Left.