Table 4. Phenotypes of loss-of-function mutations in CC components.

Node	Phenotypes of loss of function	Recovered attractor(s)	Refs.	Model
CYCD3;1	When this cyclin is depleted by sucrose starvation, cells are arrested in G1 phase; in adult leaves, triple mutant of cycd3;1–3 led to a diminished number of cells.	Period 2 oscillating between G1 and G1/S transition.	[23, 92]	A
SCF	Plants with a diminished level of SKP2 do not show obvious affected development but KRP1 is accumulated.	Similar to a normal CC but endoreduplication would be favored by the KRP1 stabilization.	[93]	A
RBR	Proliferation is promoted and cell differentiation is impaired; downregulation of RBR in rice promotes an increase of cells in S-phase.	One attractor of a normal CC (includes 81.98% of possible configurations) and other attractor oscillates among G2-S-G2 (18.02% of configurations).	[127]	A
E2Fa	Expression of E2Fb, RBR and other CC regulators decrease; more cells in G1 and G2 with respect to WT.	Fixed-point attractor with E2Fe and CYCD3;1 present suggesting an arrest in a Gap phase.	[90]	PA
E2Fb	Without information.	Fixed-point attractor representing the G1/S transition.	-	-
E2Fc	Mitotic proteins such as CYCB1;1 have increased expression, ploidy is reduced.	Fixed-point attractor of M phase arrest.	[37, 91]	PA
E2Fe	Increased endoreduplication.	Attractor of endoreduplication (period 7).	[44]	A
MYB77	Lower density of lateral roots, inconclusive data to evaluate simulation.	CC of seven configurations.	[76]	-
MYB3R1/4	Lower levels of G2/M transcripts, incomplete cell division, some embryos only have one cell with multiple nuclei.	2 attractors, the first seems a three-configurations endocycle, and the second is a CC of seven configurations where APC/C is always absent.	[43]	A
CYCB1;1	Cyclin widely used as a marker of cell proliferation, its absence is associated with differentiated cells.	Attractor characterizing endocycle (period 8), intriguingly APC/C is never present.	[128]	-
CDKB1;1	Overexpression of a dominant negative allele leads to enhanced endoreduplication.	Attractor of endoreduplication (period 11).	[129]	A
CYCA2;3	In null mutants, cells with 2C DNA content decreases before than in WT, endocycles begin before and are faster than in WT.	Attractor which is an endocycle (period 7).	[103]	PA
KRP1	No evident phenotypic effects observed but relative kinase activity increases to 1.5 in relation to WT.	A CC without alterations.	[114]	A
APC/C	Loss of CCS52A2 function (activator subunit of APC/C) produces a decrement in the number of meristematic cells without affecting endoreduplication index; cells in quiescent center become mitotically active.	Fixed-point attractor of a CC arrest previous to conclude mitosis.	[109]	PA

Summary of mutant phenotypes and recovered attractor when that mutation was simulated. Abbreviations in Model column are as in Table 3.