Skip to main content
. 2015 May 20;593(Pt 16):3513–3532. doi: 10.1113/JP270469

Figure 5. 8-Br-cAMP stimulation does not alter α7 nAChR single-channel conductance.

Figure 5

A, non-stationary current fluctuation analyses depicting mean current–variance relationship performed with PHA543613 (100 μm) elicited α7 nAChR responses from layer 1 interneurons for control and (B) 8-Br-cAMP (100 μm, in the recording pipette) stimulated interneurons. Inset shows whole-cell recorded α7 nicotinic current waveforms and their respective AC filtered waveforms for both control and 8-Br-cAMP stimulation. C, no significant change in the mean single-channel conductance is observed for α7 responses between control (n = 18) and 8-Br-cAMP treated cortical interneurons (n = 11) (P = 0.6, Wilcoxon rank sum test). D, no significant difference in the mean single-channel conductance for α7 responses is observed between control (n = 11) and 8-Br-cAMP treated HEK 293T cells (n = 15) (P = 0.6, Wilcoxon rank sum test).