Table 3.
Baseline intrinsic properties of CA3-PCs of wild type (WT) and Kcna2 mutant mice
| Genotype | Input conductance (nS)b | First spike latency (ms)b | Peak ID (pA)c | AP threshold (mV) |
|---|---|---|---|---|
| Kcna2+/+a | 3.63 ± 0.26 | 465.8 ± 26.8 | 313.8 ± 28.3 | −36.1 ± 0.7 |
| (WT) | (n = 17) | (n = 7) | (n = 7) | (n = 12) |
| Kcna2+/– | 2.92 ± 0.16 | 306.5 ± 16.2*d | 180.4 ± 15.8** | −35.9 ± 0.9 |
| (HT) | (n = 11) | (n = 7) | (n = 10) | (n = 8) |
| Kcna2–/– | 2.49 ± 0.41* | 278.1 ± 30.1* | 148.9 ± 14.7** | −37.7 ± 0.9 |
| (KO) | (n = 7) | (n = 8) | (n = 7) | (n = 8) |
a
Data for WT and homozygous KO mice are reproduced from Hyun et al. (2013).
b
Input conductance and first spike latency were measured using the same protocol as described in Hyun et al. (2013).
c
ID, 30 μm 4-AP-sensitive D-type K+ current at the test potential of −20 mV.
d
Statistical significance was tested in comparison with WT mice; means ± SEM; *P < 0.05, **P < 0.01.