Figure 7. Afferent responses to mesenteric stretch, increase in intra-arterial pressure, focal compression, localised heating and capsaicin application.

Firing of a single discriminated afferent unit (indicated by markers under firing trace) could be activated by increasing the intra-arterial pressure from 5 mmHg to 60 mmHg (A), probing a transduction site in the mesentery with a 3 mN von Frey hair (B), stretching the mesentery with a load of 15 g (C), heating a transduction site in the mesentery with 45°C Krebs solution (D) and applying 5 μl of 10⁻⁶ m capsaicin onto the mesentery (E). F, overlay of 4 action potential from each of the 5 stimuli applied.