Table 1.

Clinicopathologic characteristics of Caribbean Hispanic colorectal cancer patients according to MMR germline mutations and MMR protein-deficient status.

Study ID	Mutation	Gender	Age at CRC	Tumor Location	Family History of CRC	Family History LS Associated Cancers	Amsterdam (A)/Bethesda (B)
MLH1
8343	c.1024del16	F	43	Sigmoid	Yes	Yes	A I
9009	c.2044_2045del	F	58	Transverse	Yes	Yes	A II
9009.02	c.2044_2045del	M	42	Transverse	Yes	Yes	A II
9009.03	c.2044_2045del	M	42	Transverse	Yes	Yes	A II
9306	c.1024del16	M	39	Descending	Yes	Yes	A I
9306.01	c.1024del16	F	35		Yes	Yes	B
Pte. CUR	c.2044_2045del	M			Yes	Yes	A II
Pte. MMP	c.1855delG	M	29	Right Colon	Yes	No	B
MSH2
9106	c.IVS5-1G>T	F	47	Ascending	Yes	Yes	B
Pte. DMM	c.IVS5-1G>T	F		Endometrial (44)	Yes	Yes	B
9109	c.905T>A	F	51	Ascending	No	Yes	A II
9162	c.1705delGA	F	42	Skin	Yes	No	A II
9162.01	c.1705delGA	F			Yes	No	A II
9162.02*	c.1705delGA	F	-	-	Yes	No	A II
9162.03*	c.1705delGA	F	-	-	Yes	No	A II
9249	c.1457del4	F	39	Rectosigmoid	No	No	B
9258	c. del exons 1–3	F	57		Yes	Yes	B
Pte. JCG	c. del exons 1–3	F	32	Rectum	Yes	Yes	B
9500	c.IVS11+1G>A	M	45		Yes	No	B
Pte. HFO	c.1308insT	F	61		Yes	No	A I
9560	c.876insC	M			Yes	No	B
MSH6
9476	c.3119delTT	F	34	Cecum	Yes	Yes	B
Immunohistochemistry Analysis for MMR proteins (Absent Protein)
MLH1
9124		M	46		Yes	No	A II
9253		M	22	Colon	No	No	B
9413		M	57	Ascending	Yes	Yes	B
9420		M	30	Sigmoid	Yes	Yes	B
9473		F	34	Cecum	Yes	No	B
MSH2
8313		F	75	Rectum	No	Yes	A II
8397		F	59	Sigmoid	Yes	Yes	A I
8160		M	59	Ascending	No	Yes	B
9091.01		M	58	Right Colon	Yes	Yes	B
9423		M	43	Right Colon	No	Yes	B
17017		M	75	Rectum	No	Yes	B
9611		F	40		No	Yes	B
Pte. ESO		F	40	Rectosigmoid	No	Yes	B

^*Mutation carriers.