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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Cancer Prev Res (Phila). 2015 Jun 30;8(9):845–856. doi: 10.1158/1940-6207.CAPR-15-0130

Fig. 2. SCA frequency and hazard ratio (HR) for EA risk.

Fig. 2

SCA types are colored for cnLOH (blue), loss (green), balanced gain (yellow), allele specific copy gain (orange). SCA data were combined from baseline (T1) and last endoscopy before EA diagnosis or final endoscopy (T2) for hazard ratio (HR) estimation. Each data point in the scatter plots represents a 1Mb segment SCA HR for EA (x-axis) vs. its SCA frequency (y-axis) in nonprogressors (A) and progressors (B). The plots show all 1Mb segments in which the frequency in nonprogressors and/or progressors is significantly larger than zero (statistical significance adjusted for multiple comparisons). Many of the 1Mb segments with SCA were correlated due to whole chromosome arm alterations or large chromosomal events spanning many Mb. SCA HR (x-axis) and genomic location (y-axis) are shown in panel C. Regions of significant homozygous deletions with significant HR were small and few in number and therefore not plotted.