Table 3.

Comparison of baseline demographic and clinical measures of disease severity across subgroups with and without comorbid anxiety and depression

	No anxiety / no depression (n=102)		Anxiety w/o depression (n=16)		Depression w/o anxiety (n=16)		Anxiety & depression (n=14)
Baseline Characteristics:	Mean [SD]	N(%)	Mean [SD]	N(%)	Mean [SD]	N(%)	Mean [SD]	N(%)	p-value
Age (years)	54.2 [14.4]		46.1 [13.5]		49.6 [15.4]		46.5 [17.4]		0.08
Follow-up duration (months)	15.7 [4.9]		17.8 [5.9]		17.6 [4.7]		15.4 [4.7]		0.20
Male		58 (57%)		5 (31%)		5 (31%)		5 (36%)	----
Female		44 (43%)		11 (69%)		11 (69%)		9 (64%)	0.06
Previous sinus surgery		48 (47%)		6 (38%)		7 (44%)		8 (57%)	0.75
Nasal polyposis		47 (46%)		5 (31%)		4 (25%)		5 (36%)	0.31
Septal deviation		44 (43%)		9 (56%)		11 (69%)		6 (43%)	0.23
Turbinate hypertrophy		25 (25%)		2 (13%)		3 (19%)		1 (7%)	0.37
Asthma		32 (31%)		6 (38%)		7 (44%)		3 (21%)	0.58
Aspirin intolerance		8 (8%)		0 (0%)		2 (13%)		0 (0%)	0.36
Allergies (history)		14 (14%)		1 (6%)		3 (19%)		1 (7%)	0.66
Allergies (mRAST confirmed)		43 (42%)		5 (31%)		5 (31%)		3 (21%)	0.39
Depression		0 (0%)		0 (0%)		16 (100%)		14 (100%)	<0.001
Current tobacco use		6 (6%)		4 (25%)		0 (0%)		1 (7%)	0.03
Alcohol use		62 (61%)		6 (38%)		6 (38%)		2 (14%)	0.003
Oral steroid dependency		1 (1%)		0 (0%)		0 (%)		1 (7%)	0.25
Clinical measures of disease severity:
Computed tomography (CT) score	14.4 [6.0]		14.3 [5.3]		12.4 [6.0]		12.6 [6.1]		0.52
Endoscopy score	7.3 [3.4]		7.6 [3.6]		6.7 [4.5]		7.3 [4.0]		0.76
BSIT Olfactory function score	8.6 [3.3]		9.4 [3.0]		8.9 [3.1]		8.5 [3.4]		0.84

SD, standard deviation; mRAST, modified radioallergosorbent testing; BSIT, Brief Smell Identification Test. p-values represent omnibus test statistics across all four patient subgroups.