C/EPBδ was involved in SOCS3-enhanced inflammatory reactivities in IgG IC-treated macrophages. A, B, and C, indicated plasmids were transduced into RAW-Neo cells, and RAW-SOCS3 cells, respectively. 48 h later, the cells were treated with or without 100 μg/ml IgG IC for 4 h. Then cells were lysed and subjected to luciferase assays. Data were expressed as means ± S. E. M. (n=3, biological replicates). **, and *** indicated statistically significant difference— p < 0.01, and p < 0.001, respectively. D, RAW-Neo and RAW-SOCS3 cells were treated with or without 100 μg/ml IgG IC for 4 h. Then total proteins were extracted, and Western blot were performed by using rabbit anti-C/EBPδ antibody, and anti-GAPDH antibody, respectively. The level of GAPDH was shown at the bottom as a loading control.