Table 1.

Summary of the top GWAS and imputed SNP associations with metastasis at diagnosis in the discovery and replication studies.

dbSNP locus	Chr: Positiona	Alleleb	Stage	Ancestryc	Cases with mets.		Cases without mets.		P value	OR (95% CI)
					Total	EAF	Total	EAF
rs2890982	Chr9: 14181653	C/T	Discovery	EUR	122	0.25	419	0.11	4.36 × 10−7	2.69 (1.83–3.94)
9p24.1			Replication 1	EUR	24	0.33	61	0.12	3.71 × 10−3	3.38 (1.47–7.80)
			Replication 2	EUR	19	0.16	122	0.13	0.571	1.35 (0.47–3.87)
			Combined	EUR	165		602		4.98 × 10−8	2.60 (1.87–3.62)
rs7034162	Chr9: 14190287	T/A	Discovery	EUR	122	0.25	419	0.11	1.37 × 10−7	2.87 (1.94–4.24)
9p24.1			Replication 1	EUR	24	0.29	61	0.10	4.03 × 10−3	3.14 (1.37–7.20)
			Replication 2	EUR	19	0.11	122	0.12	0.723	0.81 (0.25–2.62)
			Combined	EUR	165		602		3.29 × 10−8	2.62 (1.86–3.68)
			Replication 3	AFR	22	0.43	39	0.25	0.061	2.08 (0.97–4.47)
			Replication 4	Brazil	40	0.21	67	0.12	0.078	1.97 (0.93–4.18)
			Combined	All	227		708		1.22 × 10−9	2.43 (1.83–3.24)

Abbreviations: EAF, effect (coded) allele frequency; mets., metastasis at diagnosis; OR, odds ratio; CI, confidence interval.

EUR, European ancestry; AFR, African ancestry; Brazil, Brazilian ancestry.

^aBuild 36 position;

^bReference/Effect allele;

^cAncestry based on a STRUCTURE and principal component analysis.