Table 2.

Change from Week 0 to Week 24 for HCC biomarkers, SAMe metabolites and markers of oxidative stress.

	Control					SAMe
	N	Week0	Week24	Week24- Week0	SDD	N	Week0	Week24	Week24- Week0	SDD	Difference between arms	p-value
AFP	40	35.81	41.66	5.86	29.21	43	34.62	32.69	− 1.93	20.30	7.78	0.160
DCP	26	0.98	1.62	0.65	1.49	27	0.96	1.22	0.26	0.98	0.39	0.266
AFP-L3	26	7.87	8.20	0.34	3.49	27	7.57	7.71	0.14	1.15	0.19	0.789
SAMe	41	121.47	112.38	− 9.09	54.62	43	102.43	516.67	414.24	744.37	− 423.33	<0.001*
SAH	41	36.36	32.90	− 3.46	13.10	43	32.36	48.68	16.33	28.21	− 19.78	<0.001*
SAM/SAH	41	3.45	3.54	0.09	1.71	43	3.31	8.62	5.31	9.06	− 5.22	<0.001*
Methionine	41	41.21	38.31	− 2.89	23.67	43	39.71	40.13	0.42	18.79	− 3.32	0.478
tHcy	41	9.74	9.07	− 0.68	2.48	43	8.95	9.22	0.27	2.39	− 0.94	0.080
tGSH	41	1.97	2.26	0.29	1.23	43	2.26	2.71	0.46	1.43	− 0.17	0.563
MDA	41	3.38	3.38	0.00	1.16	43	2.76	2.75	− 0.01	0.85	0.01	0.983
4-HNE	41	1.03	1.00	− 0.03	0.45	43	1.04	0.85	− 0.19	0.72	0.15	0.248

^*Mann-Whitney test