A 66-year-old man diagnosed with biopsy proven oligometastatic pancreas cancer in 2012. CT demonstrates (A) biopsy proven pancreas primary tumor; (B) biopsy proven liver metastasis; (C) 2nd liver metastasis. Patient was treated with gemcitabine and abraxane followed by 5-FU, leucovorin, oxaliplatin, and irinotecan. Twenty-four months after diagnosis, CT demonstrated significant radiologic response in (D) pancreas primary; (E) liver metastasis; and (F) 2nd liver metastasis. Surgical resection of pancreas and liver lesions demonstrated complete pathologic response in all three sites and patient currently has no evidence of disease 6 months post resection and 30 months after diagnosis. CT, computed tomography; 5-FU, 5-fluorouracil.