Table 1. Association between RHBDD1 expression and clinicopathologic parameters in 539 colorectal cancer patients.

Clinicopathologic parameters	N	RHBDD1 expression		P value*
		Negative	Positive
Gender				0.193
Male	327	182	145
Female	212	130	82
Age				0.080
≤60	286	176	110
>60	253	136	117
Smoking				0.313
Yes	75	39	36
No	464	273	191
Alcohol abuse				0.745
Yes	52	29	23
No	487	283	204
Family history†				0.399
Yes	57	30	27
No	482	282	200
Differentiation				0.006*
Low	98	44	54
Moderate	398	237	161
High	43	31	12
Necrosis				0.667
Yes	23	12	11
No	516	300	216
Lymphatic vessel
Yes	31	13	18
No	508	299	209
pTNM				0.0001*
I	1	0	1
II	340	220	120
III	198	92	106
pT				0.408
T1	1	0	1
T2	6	2	4
T3	518	302	216
T4	14	8	6
pN				0.0002*
N0	341	220	121
N1	134	61	73
N2	64	31	33

pTNM, pathological tumor-node-metastasis; pT, pathological tumor; pN, pathological node.

^*The significance of RHBDD1 expression in clinicopathologic parameters was calculated by χ² test and Fisher's exact test was used when over 25% cells had expected count <5.

^†Family history indicates that the immediate family member of the patient has a history of digestive system tumours.