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. 2015 Aug 28;6:8041. doi: 10.1038/ncomms9041

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YUC6 functions in auxin biosynthetic pathways through its YUC activity. YUC6 also possesses TR activity, thereby reducing ROS content. FAD- and NADPH-binding sites are essential for both YUC and TR activities. Cys-85 is required only for TR activity. In addition, YUC6 displays holdase chaperone activity in a Cys-85-dependent manner. Thus, as an auxin biosynthetic enzyme YUC6 functions in plant development and as a TR-like (and chaperone) protein it functions in ROS regulation and protection against oxidative and drought stresses.