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. 2015 Aug 27;6:8100. doi: 10.1038/ncomms9100

Figure 6. PAQR3 modulates SREBP activity and lipid biosynthesis mainly at low dietary cholesterol levels.

Figure 6

Seven-week-old male C57BL/6J mice were injected with control or PAQR3-shRNA adenovirus i.v. Seven days after injection, the mice (n=7 per group) were subjected to diets containing different cholesterol levels ad libitum for 3 days, and then killed for analysis. (a–c) Western blotting analysis, gene expression levels as measured by RT–PCR and lipid measurement in the livers of mice fed with a diet containing 0% cholesterol. (d–f) Western blotting analysis, mRNA and lipid levels in the livers of mice fed with diets of varying cholesterol concentrations. All data show mean±s.d., *P<0.05, **P<0.01, ***P<0.001 by Student's t-test, NS, not significant. All experiments were repeated at least twice with similar results and representative data are shown.