Table 3.
Comparison Between Triggers of Diagnosis
| 1935–1999 | 2000–2012 | 1935–1999 | 2000–2012 | ||||
|---|---|---|---|---|---|---|---|
| Clinically occult(n=59) | Clinically occult(n=113) | Total clinically occult(n=172) | Clinically recognized(n=203) | Clinically recognized(n=100) | Total clinically recognized(n=303) | p Value (occult vs. clinically recognized) | |
| Age at diagnosis in years, mean (SD) | 52.3 (20) | 49.6 (14.9) | 50.6 (17) | 44.2 (16) | 42.7 (14.14) | 43.7 (15.8) | 0.01 |
| Female, n (%) | 37 (63) | 79 (70) | 116 (68) | 157 (77) | 70 (70) | 226 (74) | 0.09 |
| Size of tumor, mean (SD) | 0.98 (1) | 1.3 (1) | 1.19 (1) | 2.3 (1.6) | 2.26 (1.2) | 2.3 (1.5) | 0.01 |
| MACIS score, mean (SD)* | 5 (1.7) | 4.6 (1.2) | 4.8 (1.5) | 4.8 (1.8) | 4.7 (1.4) | 4.8 (1.7) | 0.86 |
| MACIS score<6, n (%)* | 41 (70) | 94 (87) | 135 (82) | 177 (87) | 81 (89) | 258 (87) | 0.08 |
| Papillary, n (%) | 53 (90) | 108 (96) | 161 (94) | 162 (80) | 91 (91) | 253 (83) | 0.001 |
| Follicular, n (%) | 2 (3) | 3 (2) | 5 (3) | 13 (6) | 3 (3) | 16 (5) | 0.22 |
| Hürthle, n (%) | 1 (2) | 1 (1) | 2 (1) | 17 (8) | 0 (0) | 17 (6) | – |
| Medullary, n (%) | 3 (5) | 1 (1) | 4 (2) | 5 (2) | 3 (3) | 8 (3) | – |
| Metastatic, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (1) | 1 (0) | – |
| Anaplastic, n (%) | 0 (0) | 0 (0) | 0 (0) | 6 (3) | 0 (0) | 6 (2) | – |
| Lymphoma, n (%) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (2) | 2 (1) | – |
| Total/near total thyroidectomy, n (%) | 11 (19) | 88 (78) | 99 (52) | 48 (23) | 90 (90) | 138 (45) | 0.01 |
| Hemithyroidectomy, n (%) | 22 (37) | 19 (17) | 41 (20) | 130 (64) | 5 (5) | 135 (45) | 0.01 |
| Subtotal thyroidectomy, n (%) | 5 (8) | 4 (4) | 9 (5) | 16 (8) | 5 (5) | 21 (7) | 0.46 |
| Other, n (%) | 1 (2) | 2 (2) | 3 (2) | 0 (0) | 0 (0) | 0 (0) | – |
| Not able to assess, n (%) | 20 (34) | 0 (0) | 20 (21) | 10 (5) | 0 (0) | 10 (3) | 0.01 |