Table 3.
Symbol | RNA-seq | Microarray | |||||||
---|---|---|---|---|---|---|---|---|---|
miRBase acc# | miRBase family | MiRBase fam acc # | Ctrl RPM | AUD RPM | % Δ AUD | P-value | % Δ AUD | P-value | |
Tier A: RNA-seq p < 0.05, Array p < 0.1, consistent % Δ AUD | |||||||||
mir-96 | MI0000098 | mir-96 | MIPF0000072 | 4.6 | 11.3 | 142.6 | 0.031 | 15.0 | 0.059 |
mir-320b-1 | MI0003776 | mir-320 | MIPF0000163 | 61.0 | 144.6 | 137.1 | 0.004 | 22.2 | 0.071 |
mir-1976 | MI0009986 | mir-1976 | MIPF0001633 | 4.1 | 9.9 | 138.1 | 0.039 | 24.1 | 0.081 |
Tier B: RNA-seq p < 0.05, consistent % Δ AUD | |||||||||
mir-24-1 | MI0000080 | mir-24 | MIPF0000041 | 31.3 | 90.5 | 189.4 | 0.008 | 6.2 | 0.338 |
mir-30a | MI0000088 | mir-30 | MIPF0000005 | 108.2 | 209.9 | 94.0 | 0.014 | 5.1 | 0.860 |
mir-92b | MI0003560 | mir-25 | MIPF0000013 | 7141.9 | 4553.8 | −36.2 | 0.016 | −8.2 | 0.312 |
miR-96-5p | MIMAT0000095 | mir-96 | MIPF0000072 | 111.7 | 252.0 | 125.5 | 0.018 | 8.0 | 0.455 |
mir-127 | MI0000472 | mir-127 | MIPF0000080 | 68.6 | 158.9 | 131.5 | 0.021 | 8.4 | 0.455 |
mir-136 | MI0000475 | mir-136 | MIPF0000099 | 4.4 | 9.7 | 121.2 | 0.035 | 1.5 | 0.760 |
miR-301a-3p | MIMAT0000688 | mir-130 | MIPF0000034 | 205.9 | 85.1 | −58.7 | 0.045 | −2.4 | 0.878 |
mir-320b-2 | MI0003839 | mir-320 | MIPF0000163 | 61.3 | 148.8 | 142.9 | 0.004 | 5.2 | 0.333 |
mir-421 | MI0003685 | mir-95 | MIPF0000098 | 15.5 | 30.3 | 95.6 | 0.020 | 9.0 | 0.725 |
miR-660-5p | MIMAT0003338 | mir-188 | MIPF0000113 | 196.9 | 99.7 | −49.4 | 0.028 | −10.2 | 0.451 |
mir-671 | MI0003760 | mir-671 | MIPF0000358 | 14.8 | 44.4 | 200.0 | 0.003 | 4.2 | 0.692 |
mir-3615 | MI0016005 | mir-3615 | MIPF0001540 | 50.1 | 78.3 | 56.4 | 0.031 | 1.3 | 0.881 |
mir-3676 | MI0016077 | 2.1 | 11.1 | 437.1 | 0.027 | 12.9 | 0.218 |
RNA-sequencing of human serum samples determined miRNAs with nominally significant alterations and trends in patients with AUDs. Comparison with microarray data subsequently identified changes that were consistent across platforms. MicroRNAs were classified into two tiers based on concurrence of both analyses. Where available, microRNA families for each miRNA are also listed. Note that these are nominal (uncorrected) p values
RPM normalized reads per million