Table 4.
Variables correlated with Tiers A or B miRNAs in AUD subjects (p < 0.05)
| miRNA | Variable | AUD | Ctrl | All | |||||
|---|---|---|---|---|---|---|---|---|---|
| R | P-value | N | R | P-value | N | R | P-value | ||
| In Tiers A and B | |||||||||
| miR-660-5p | Drinking days last month | 0.626 | 0.030 | 6 | |||||
| mir-421 | Drinking days last week | 0.482 | 0.020 | 12 | |||||
| mir-320b-1 | Drinks per drinking day | 0.599 | 0.007 | 15 | |||||
| mir-320b-2 | Drinks per drinking day | 0.934 | 0.002 | 15 | |||||
| mir-24-1 | Gamma-glutamyl transferase | 0.448 | 0.034 | 16 | −0.558 | 0.276 | 9 | 0.312 | 0.084 |
| mir-92b | Gamma-glutamyl transferase | 0.691 | 0.005 | 17 | 0.306 | 0.329 | 10 | 0.173 | 0.350 |
| mir-421 | Gamma-glutamyl transferase | 0.476 | 0.022 | 14 | −0.396 | 0.404 | 9 | −0.024 | 0.914 |
| mir-671 | Gamma-glutamyl transferase | 0.594 | 0.043 | 16 | −0.016 | 0.968 | 9 | 0.538 | 0.001 |
| mir-1976 | Gamma-glutamyl transferase | 0.474 | 0.023 | 9 | 0.595 | 0.091 | 7 | 0.509 | 0.017 |
| mir-3615 | Gamma-glutamyl transferase | 0.476 | 0.028 | 17 | −0.002 | 0.997 | 10 | 0.046 | 0.817 |
| mir-24-1 | Left inferior frontal triangular gyrus | 0.548 | 0.006 | 16 | 0.547 | 0.068 | 9 | 0.060 | 0.768 |
| mir-136 | Left inferior frontal triangular gyrus | 0.567 | 0.005 | 7 | 0.211 | 0.708 | 5 | −0.108 | 0.753 |
| mir-1976 | Left inferior frontal triangular gyrus | 0.531 | 0.009 | 9 | −0.069 | 0.887 | 7 | −0.327 | 0.307 |
| mir-320b-2 | Left ventral diencephalon | 0.930 | 0.002 | 17 | −0.606 | 0.213 | 10 | −0.229 | 0.311 |
| miR-301a-3p | Letter fluency score | 0.732 | 0.025 | 6 | 0.797 | 0.055 | 4 | 0.480 | 0.077 |
| mir-320b-2 | Letter fluency score | 0.771 | 0.032 | 17 | −0.396 | 0.371 | 9 | −0.467 | 0.065 |
| miR-660-5p | Letter fluency score | 0.602 | 0.040 | 6 | 0.700 | 0.114 | 4 | 0.753 | 0.001 |
| mir-30a | Right anterior collateral transverse sulcus | 0.467 | 0.026 | 17 | 0.080 | 0.819 | 10 | −0.240 | 0.292 |
| miR-301a-3p | Right anterior collateral transverse sulcus | 0.845 | 0.005 | 6 | 0.652 | 0.152 | 5 | 0.728 | 0.002 |
| mir-92b | Right cingulomarginal sulcus | 0.547 | 0.037 | 17 | 0.209 | 0.524 | 10 | 0.390 | 0.019 |
| mir-24-1 | Right pars opercularis | 0.441 | 0.037 | 16 | −0.009 | 0.983 | 9 | −0.099 | 0.655 |
| mir-136 | Right pars opercularis | 0.447 | 0.034 | 7 | −0.556 | 0.496 | 5 | −0.287 | 0.443 |
Pearson correlation analysis of miRNA expression levels in AUD subjects reveal significant relationships between specific miRNA expression levels and other medical, drinking and neuroimaging variables that were significantly different in AUD subjects
R Pearson correlation coefficient, N number of pairs used in the calculation