Table 2.
PAI-1 -844 A/G and ACE Intron 16 I/D gene polymorphisms related to markers of fibrinolysis. Plasma concentrations of PAI-1 preoperatively – and of t-PA/PAI-1 complex and D-dimer postoperatively after on-pump cardiac surgery
| Genetic polymorphism | n | PAI-1, ng/mL, preoperatively | t-PA/PAI-1, ng/mL, 24 h postoperatively | D-dimer, ng/mL 0 h | D-dimer, ng/mL 6 h | D-dimer, ng/mL 24 h |
|---|---|---|---|---|---|---|
| PAI-1 -844 A/G | ||||||
| A/A | 23 | 28 ± 12* | 3.8 ± 1.8 | 251 ± 170 | 289 ± 210 | 234 ± 187 |
| A/G | 38 | 24 ± 13 | 3.6 ± 2.1 | 312 ± 213 | 312 ± 200 | 184 ± 129* |
| G/G | 22 | 18 ± 12* | 3.4 ± 2.4 | 287 ± 255 | 255 ± 203 | 267 ± 168* |
| P value | 0.004 | NS | NS | NS | 0.04 | |
| ACE intron 16 I/D | ||||||
| D/D | 19 | 27 ± 13* | 3.6 ± 2 | 234 ± 161* | 244 ± 182 | 208 ± 173 |
| I/D | 42 | 24 ± 13 | 4 ± 2.3* | 294 ± 238 | 291 ± 204 | 247 ± 165 |
| I/I | 22 | 18 ± 11* | 2.8 ± 1.7* | 376 ± 203* | 331 ± 218 | 274 ± 167 |
| P value | 0.02 | 0.02 | 0.03 | NS | NS | |
Data presented as the mean ± standard error of the mean
PAI-1 Plasminogen activator inhibitor type-1, A Adenosine, G Guanine, ACE Angiotensin converting enzyme, I Insertion, D Deletion, n Number of patients, t-PA Tissue plasminogen activator, 0 h Immediately after surgery, 6, 24 h 6 and 24 h postoperatively. *P < 0.05 between genotypes