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. 2015 Sep 5;17(1):240. doi: 10.1186/s13075-015-0733-z

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© Erwin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Western blots for fibromodulin, biglycan, and hyaluronan and proteoglycan link protein 1 (HAPLN1) expression in non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine nucleus pulposus (NP) homogenates. Lane (i) depicts the expression of these proteins in articular cartilage used as a control. Lanes (ii) and (iii) represent the expression of these proteins in intervertebral disc NP homogenates for CD (beagle) and NCD (mongrel) samples. It is clear that there is strong expression in both articular cartilage and CD samples for all three proteins. However, in the NCD samples, fibromodulin and HAPLN1 are undetectable, and the expression of biglycan is markedly reduced