Table 4.
Clinical factors and comorbidities associated with non-AIDS deaths by ART Era.
| Overall (1995-2011) | Early Era (1995-2001) | Late Era (2002-2011) | ||||
|---|---|---|---|---|---|---|
| Deaths | 400 | 207 | 193 | |||
| Non-AIDS | 225 | 89 | 136 | |||
| AIDS | 175 | 118 | 57 | |||
| Odds Ratio1 (95%CI) | Adjusted Odds Ratio2 (95% CI) | Odds Ratio1 (95%CI) | Adjusted Odds Ratio2 (95% CI) | Odds Ratio1 (95%CI) | Adjusted Odds Ratio2 (95% CI) | |
| Clinical Factors | ||||||
| Age (per year) | 1.06 (1.04,1.08) | * | 1.03 (1.01,1.06) | * | 1.07 (1.03,1.1) | * |
| Male Gender | 0.98 (0.6,1.5) | * | 1.04 (0.6,1.9) | * | 1.1 (0.6, 2.0) | * |
| White Race (vs Non-white) | 0.8 (0.5, 1.2) | * | 1.2 (0.6, 2.2) | * | 0.4 (0.2,0.8) | * |
| CD4 >200 cells/mm3 ## | 37.6 (14.8,95.5) | 16.5 (5.3,51.4) | 24.4 (7.1,83.2) | 17.4 (3.4,88.3) | 45.4 (10.5,195.5) | 25.9 (5.0,134.5) |
| HIV VL ≤400 copies/ml& | 13.6 (5.2,35.3) | 7.5 (2.3,24.4) | 9.4 (1.2,76.6) | * | 15.6 (5.2,46.4) | 10.9 (2.4,48.8) |
| On ART | 2.3 (1.5,3.5) | * | 1.6 (0.9, 2.8) | * | 2.7 (1.3,5.3) | * |
| Comorbidities | ||||||
| Lung Disease# | 1.9 (1.01,3.5) | * | 2.4 (1.02,5.5) | * | 1.5 (0.6, 3.9) | * |
| Kidney Disease# | 3.5 (2.1,6.0) | * | 3.5 (1.7,7.3) | 4.9 (1.4,17.8) | 3.1 (1.4,7.2) | * |
| Depression | 1.6 (0.8, 3.2) | * | 2.5 (0.9,6.6) | * | 0.95 (0.4, 2.5) | * |
| Substance Abuse# | 1.9 (1.1,3.6) | * | 3.7 (1.5,9.5) | * | 0.9 (0.4, 2.1) | * |
| Diabetes | 2.3 (1.2,4.5) | * | 2.0 (0.7,5.5) | * | 1.9 (0.7, 5.0) | * |
| Liver Disease# | 3.6(2.4,5.4) | 4.5 (2.2,9.3) | 2.4 (1.4,4.3) | 4.4 (1.5,12.7) | 4.3 (2.2,8.3) | 7.5 (2.4,23.4) |
| Cardiovascular Disease# | 2.9 (1.8,4.6) | 4.2 (1.8,9.9) | 1.8 (0.9,3.5) | * | 4.6 (2.0,10.3) | 6.8 (1.9,24.0) |
1
: Univariate logistic regression
2
: Multivariable stepwise Logistic regression; variables denoted with an
*
did not remain in the multivariable stepwise model
Italicized font signifies significant factors
#
Kidney disease = CKD or Dialysis
Liver Disease = Hepatitis B or Hepatitis C infection or Liver Cirrhosis
Lung Disease = COPD or Asthma
Cardiovascular Disease = CHF or CAD or HTN
Substance Abuse is Polysubstance abuse or Alcohol abuse
##
: There were 5 AIDS deaths in patients with CD4>200 cells/mm3 (3 Early era; 2 Late era) hence the 95% CI are wide
&
: There were 5 AIDS deaths in patients with vL≤400 copies/ml (1 Early era; 4 Late era) hence the 95% CI are wide