Table 2.
Overall and study visit adherence and agreement results for riboflavin, pill count and medication diary for the study cohort.
| Study Visit | Adherence Measurement | Agreement Statistics | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pill Counta | Diarya | Riboflavinb | Pill Count/Diary | Pill Count/Riboflavin | Diary/Riboflavin | ||||||||
|
|
|||||||||||||
| N | Mean (SD) | % Comp | Mean (SD) | % Comp | Mean (SD) | % Comp | % Agree | Kappa | % Agree | Kappa | % Agree | Kappa | |
| Visit 2 | 103 | 92.3 (14.9) | 86.3 % | 93.6 (12.6) | 90.0 % | 3829 (2581) | 82.5 % | 90.9 % | 0.82 | 74.5 % | 0.49 | 79.0 % | 0.59 |
| Visit 4 | 78 | 90.9 (14.0) | 84.4 % | 93.6 (12.2) | 90.8 % | 4211 (2579) | 87.2 % | 93.3 % | 0.87 | 74.0 % | 0.48 | 80.3 % | 0.61 |
| Visit 6 | 74 | 91.1 (18.8) | 84.9 % | 93.2 (18.7) | 94.4 % | 3216 (2515) | 77.0 % | 90.0 % | 0.80 | 72.6 % | 0.45 | 77.5 % | 0.55 |
| Visit 8 | 67 | 96.6 (10.1) | 94.0 % | 96.6 (10.6) | 92.5 % | 4212 (3024) | 77.6 % | 98.5 % | 0.97 | 77.6 % | 0.55 | 76.1 % | 0.52 |
| Visit 10 | 66 | 93.8 (15.1) | 87.7 % | 95.6 (10.2) | 90.8 % | 2864 (2463) | 72.7 % | 90.6 % | 0.81 | 69.2 % | 0.38 | 70.8 % | 0.42 |
| Visit 12 | 64 (11.5) | 95.6 % | 92.1 (9.0) | 96.5 % | 93.4 (2668) | 2784 % | 62.5 % | 100 | 1.00 % | 61.9 | 0.24 % | 62.3 | 0.25 |
| Overall | 93.2 (14.5) | 87.9 | 94.7 (12.7) | 91.8 | 3562 (2684) | 77.4 % | 93.6 % | 0.87 | 72. 0% | 0.44 | 75.0 % | 0.50 | |
a
Pill count and Diary data are shown as mean (SD) proportion of study doses taken as a function of the number of study doses prescribed. Percent compliant (% Comp) is shown as the proportion of participants with ≥ 80% of study doses taken at that visit.
b
Riboflavin data are shown as the mean (SD) ng/ml of riboflavin detected at each visit. Percent compliant is shown as the proportion of participants with ≥ 900 ng/ml riboflavin detected at that visit. The Prevalence and Bias Adjusted Kappa (PABAK) is shown.