Fig. 1.

Putative targets in HIV eradication. The HIV reservoir is established primarily in resting memory T cells and other T-cell subtypes (right), though other lineages including monocytes are also implicated (left). Cure strategies currently being explored target this reservoir at varying points, including early therapy to minimize reservoir size (as in the Mississippi baby); reactivation of HIV from its latent state; direct targeting of the reservoir cells; and interruption of maintenance of the reservoir by preventing cycles of reinfection. These approaches each have specific targets, and in many cases may be complementary. Other cell types including monocytes (not shown) have also been implicated in reservoir persistence