Table 1.
Top five genes showing the strongest association with initiation of cannabis use
| Gene name (Gene ID) | Chr | Start position | Number of SNPs assigned to gene | Key SNPs position (rs number) | Gene feature | Key SNPs P-value | Gene P-value | Molecular function according to gene ontology annotation |
|---|---|---|---|---|---|---|---|---|
| Zinc finger protein 181 (ZNF181) | 19 | 35225479 | 2 | 35221228 (rs35487050) |
Upstream | 1.6 × 10−7 | 3.7 × 10−6 | Nucleic acid binding; metal ion binding |
| microRNA 643 (MIR643) | 19 | 52785049 | 10 | 52787471 (rs2434422) |
Intronic | 3.7 × 10−6 | 3 × 10−5 | – |
| 52788044 (rs321908) |
Intronic | 8.5 × 10−6 | – | |||||
| Zinc finger protein 766 (ZNF766) | 19 | 52772823 | 41 | 52787471 (rs2434422) |
Intronic | 3.7 × 10−6 | 1.1 × 10−4 | Nucleic acid binding; metal ion binding |
| 52788044 (rs321908) |
Intronic | 8.5 × 10−6 | – | |||||
| 52770905 (rs57523152) |
Upstream | 3.3 × 10−5 | – | |||||
| 52790542 (rs139570481) |
Intronic | 2.3 × 10−4 | – | |||||
| 52792311 (rs147711278) |
Intronic | 3.4 × 10−4 | – | |||||
| 52775301 (rs2089275) |
Intronic | 1 × 10−2 | – | |||||
| Phosphatidylinositol-specific phospholipase C, X domain containing 2 (PLCXD2) | 3 | 111393522 | 60 | 111416310 (rs1355767) |
Intronic | 1.1 × 10−6 | 1.1 × 10−4 | Phosphoric diester hydrolase activity |
| 111399209 (rs7651713) |
Intronic | 1.2 × 10−6 | – | |||||
| 111460129 (rs57628489) |
Intronic | 1.3 × 10−2 | – | |||||
| 111430969 (rs16858448) |
Intronic | 1.5 × 10−2 | – | |||||
| 111438443 (rs12637233) |
Intronic | 1.5 × 10−2 | – | |||||
| 111479048 (rs7643067) |
Intronic | 1.6 × 10−2 | – | |||||
| 111470751 (rs74571144) |
Intronic | 1.6 × 10−2 | – | |||||
| 111463864 (rs75923425) |
Intronic | 1.6 × 10−2 | – | |||||
| 111453629 (rs4682300) |
Intronic | 1.8 × 10−2 | – | |||||
| 111530499 (rs138770435) |
Intronic | 2.7 × 10−2 | – | |||||
| 111482694 (rs139568104) |
Intronic | 3 × 10−2 | – | |||||
| 111443003 (rs9854875) |
Intronic | 3.2 × 10−2 | – | |||||
| 111449944 (rs7624162) |
Intronic | 3.2 × 10−2 | – | |||||
| 111514564 (rs11715999) |
Intronic | 4 × 10−2 | – | |||||
| Prefoldin-like chaperone (URI1) | 19 | 30433145 | 15 | 30511638 (rs57192507) |
Downstream | 2.2 × 10−5 | 1.8 × 10−4 | Unfolded protein binding |
| 30465196 (rs7249169) |
Intronic | 2.7 × 10−5 | – | |||||
| 30509036 (rs73924148) |
Downstream | 2.7 × 10−5 | – | |||||
| 30442432 (rs77858500) |
Intronic | 3.1 × 10−5 | – | |||||
| 30432202 (rs58563661) |
Intronic | 1.1 × 10−4 | – | |||||
| 30418009 (rs61340893) |
Intronic | 2.9 × 10−2 | – |