Table 2.
Top five genes showing the strongest association with age at onset of cannabis use
| Gene name (Gene ID) | Chr | Start position | Number of SNPs assigned to gene | Key SNPs position (rs number) | Gene feature | Key SNPs P-value (lambda adjusted) | Gene P-value | Molecular function according to gene ontology annotation |
|---|---|---|---|---|---|---|---|---|
| Gem (nuclear organelle) associated protein 5 (GEMIN5) | 5 | 154266975 | 3 | 154289310 (rs148816132) |
Intronic | 1.4 × 10−5 | 4.7 × 10−4 | Protein binding; snRNA binding |
| 154272889 (rs816735) |
Intronic | 0.038 | – | |||||
| Uncharacterized LOC101927911 (LOC101927911) | 17 | 2865540 | 9 | 2871545 (rs4790396) |
Intronic | 1.6 × 10−4 | 4.7 × 10−4 | – |
| Metallothionein 4 (MT4) | 16 | 56598960 | 13 | 56598707 (rs141262031) |
Upstream | 1.9 × 10−5 | 5.2 × 10−4 | Copper ion binding; zinc ion binding. |
| 56605477 (rs4784686) |
Downstream | 0.001 | – | |||||
| 56596812 (rs71387120) |
Upstream | 0.003 | – | |||||
| Kinesin family member 4B (KIF4B) | 5 | 154393259 | 1 | 154401490 (rs115299630) |
Downstream | 3.9 × 10−5 | 5.3 × 10−4 | Nucleotide binding; DNA binding; microtubule motor activity; ATP binding; microtubule binding; |
| Peptidylprolyl isomerase G (cyclophilin G) (PPIG) | 2 | 170440849 | 53 | 170439011 (rs118138006) |
Upstream | 3.5 × 10−5 | 5.8 × 10−4 | Peptidyl-prolyl cis–trans isomerase activity; isomerase activity; |
| 170444201 (rs78740435) |
Intronic | 5.7 × 10−5 | – | |||||
| 170437115 (rs12618592) |
Upstream | 1 × 10−4 | – | |||||
| 170497179 (rs3731675) |
Downstream | 1.4 × 10−4 | – | |||||
| 170480402 (rs12612841) |
Intronic | 6.5 × 10−4 | – | |||||
| 170471270 (rs115697204) |
Intronic | 6.5 × 10−4 | – | |||||
| 170466028 (rs75173877) |
Intronic | 6.7 × 10−4 | – | |||||
| 170461257 (rs7421113) |
Intronic | 0.001 | – | |||||
| 170477394 (rs75968631) |
Intronic | 0.001 | – |