Table 1.
LRG—treatment for each study visit.
| Visit number | Trial timeline/study visits | Blood tests (renal/liver profiles/cholesterol) | Blood test (PTH) + extra sample | Dietician advice | Pittsburgh Dialysis Symptoms Index | Communicare package | BAASIS | Other events |
|---|---|---|---|---|---|---|---|---|
| 0 | −6 weeks to −3 weeks | Potential participants identified from patient records Contact made; PIS provided |
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| 1 | −3 weeks | ✓ | Consent Washout period commences |
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| 2 | Randomisation week 0 |
✓ | ✓ | ✓ | Randomisation Commence oral phosphate binding trial medication— sevelamer or lanthanum |
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| 3 | 1 week after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 4 | 2 weeks after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 5 | 3 Weeks after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 6 | 4 weeks after randomisation | ✓ | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 7 | 5 weeks after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 8 | 6 weeks after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 9 | 7 weeks after randomisation | ✓ | Titrate trial medication and statins Discuss symptoms |
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| 10 | 8 weeks after randomisation |
✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 11 | 12 weeks after randomisation | ✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 12 | 16 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 13 | 20 weeks after randomisation | ✓ | ✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 14 | 24 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 15 | 28 weeks after randomisation | ✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 16 | 32 weeks after randomisation | ✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 17 | 36 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 18 | 40 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 19 | 44 weeks after randomisation | ✓ | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 20 | 48 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Titrate trial medication and statins if necessary |
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| 21 | 52 weeks after randomisation | ✓ | ✓ | Review medical history Discuss symptoms Patient's involvement in the trial ends |
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