Figure 9. Deletion of MHCII on B cells ameliorates clinical disease.
(A) Glomerular and interstitial nephritis (GN and IN) were scored from 0 to 6. (B) Proteinuria was scored from 0 to 5. Each dot represents an individual mouse. Horizontal lines represent the medians. (C) Weights of combined axillary lymph nodes and (D) spleen were measured. Data are represented as median +/− SEM. Data are pooled from 6 independent cohorts of 12 week old mice; control n=30 and CD19-Cre n=32. Statistics were calculated by two-tailed Mann-Whitney test. *p < 0.05; **p < 0.01; ***p < 0.001.
