Fig. 3. Administration of IL-10 producing B cells in combination with E2 treatment decreased activation of microglia/macrophages in the CNS.
CD11b+CD45hi activated microglia/macrophages (Fig. 3a, 3b) and CD11b+CD45low resting microglia/macrophages (Fig. 3c, 3d) were determined in individual spinal cords and brains. Data shown are representative of 4 independent experiments consisting of 6 mice per group (mean ± SEM). Statistical analysis was performed with ANOVA followed by Newman-Kuels post hoc test. Significant differences between sample means are indicated (*p≤0.05; **p≤0.01; ***p≤0.001)