Tab. 1. Clinical course of EAE in µMT−/− mice.
Statistical evaluation of EAE disease course for µMT−/− female mice treated with vehicle, 107 IL-10+ B cells, estradiol (E2), or 107 IL-10+ B cells in combination with E2, including the Cumulative Disease Index (CDI) through day 24 post-immunization for the 4 experiments (n = 3–6 mice/group/experiment) presented as mean ± SEM.
| Mice | Incidence | Onset | Peak | CDI | Mortality |
|---|---|---|---|---|---|
| Sham/Saline | 20/20 | 12.1 ± 0.4a | 5.0 ± 0.1a | 56.4 ± 2.3a | 1 |
| Sham/B cells | 11/12 | 11.0 ± 0.5b | 4.8 ± 0.4b | 51.3 ± 5.2b | 0 |
| E2/Saline | 12/19 | 20.3 ± 0.4 | 2.8 ± 0.5 | 10.4 ± 2.2 | 0 |
| E2/B cells | 7/23 | 12.1 ± 0.7 | 1.2 ± 0.4c | 4.4 ± 1.6c | 0 |
a
significant (P<0.0001) as Compared to E2 group
b
significant (P<0.0001) as Compared to E2/B cells group
c
significant (P<0.05) as Compared to E2/B cells group