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. 2014 Dec 27;50(9):975–983. doi: 10.1007/s00535-014-1030-3

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© The Author(s) 2014

Open AccessThis article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 2 — Immunohistological staining for the expressions of HIF-1α, PHD3, and Siah2 in surgical specimens from PDAC and HCC patients. a HIF-1α was positively stained in the nuclei of cancer cells in HCC specimens, but was negatively or extremely rarely stained in the PDAC specimens, and a semiquantitative analysis showed a significant difference between the groups (p < 0.05). b PHD3 was positively stained in many cancer cells in the PDAC specimens, but was negatively or weakly stained in the HCC specimens (p < 0.001). c The expression of Siah2 was negative or weak in both the PDAC and HCC specimens, but the semiquantitative analysis showed a significantly higher expression in the HCC specimens (p < 0.05)