Table S2. The ROC curve analyze results of genes greatly elevated in LUSC.
| Gene | LUAD | LUSC | Fold-change (LUSC/LUAD) | AUC value |
|---|---|---|---|---|
| DSG3 | 88±777 | 8,728±8,556 | 98.77 | 0.973 |
| KRT5 | 1,227±10,342 | 116,689±96,742 | 95.03 | 0.972 |
| DSC3 | 128±789 | 7,515±6,291 | 58.62 | 0.970 |
| CALML3 | 141±1,096 | 10,039±11,031 | 71.17 | 0.964 |
| SERPINB13 | 22±191 | 2,166±3,217 | 95.70 | 0.956 |
| KRT6B | 310±1,208 | 17,808±27,334 | 57.45 | 0.954 |
| KRT6C | 136±529 | 7,372±12,063 | 54.13 | 0.954 |
| KRT6A | 2,297±8,724 | 87,096±81,359 | 37.91 | 0.951 |
| PVRL1 | 1,204±1,177 | 11,200±7,063 | 9.30 | 0.950 |
| LOC642587 | 59±213 | 1,247±1,247 | 20.99 | 0.949 |
| PERP | 6,258±4,951 | 31,500±21,939 | 5.03 | 0.947 |
| TP63 | 325±914 | 10,976±9,139 | 33.72 | 0.946 |
| TRIM29 | 861±1,930 | 11,291±7,291 | 13.10 | 0.945 |
| ATP1B3 | 1,866±1,138 | 9,231±6,592 | 4.94 | 0.945 |
| FAT2 | 125±383 | 3,737±3,587 | 29.82 | 0.943 |
| CLCA2 | 87±691 | 6,787±7,536 | 77.23 | 0.943 |
| SPRR2A | 43±546 | 4,036±8,211 | 93.51 | 0.940 |
| JAG1 | 1,118±1,157 | 7,365±7,830 | 6.58 | 0.939 |
| KRT14 | 315±3,191 | 26,428±57,383 | 83.77 | 0.939 |
| SERPINB5 | 358±904 | 4,421±3,570 | 12.32 | 0.937 |
| KRT13 | 225±2,423 | 18,866±41,338 | 83.76 | 0.934 |
| CSTA | 190±403 | 4,222±5,543 | 22.20 | 0.934 |
| PKP1 | 882±2,176 | 19,788±16,151 | 22.42 | 0.934 |
| DAPL1 | 15±102 | 1,098±1,932 | 69.02 | 0.933 |
| IRF6 | 647±369 | 3,108±1,757 | 4.80 | 0.932 |
| KRT16 | 310±1,070 | 17,386±35,463 | 56.03 | 0.932 |
| SLC6A8 | 965±1,028 | 7,254±5,830 | 7.52 | 0.929 |
| SPRR2E | 13±179 | 1,158±3,196 | 84.41 | 0.929 |
| A2ML1 | 106±1,345 | 1,717±3,166 | 16.10 | 0.929 |
| GPC1 | 1,375±1,171 | 9,223±8,003 | 6.71 | 0.926 |
| HR | 60±115 | 1,104±1,530 | 18.30 | 0.923 |
| KRT17 | 2,926±8,839 | 62,551±69,399 | 21.37 | 0.921 |
| COL7A1 | 442±945 | 5,390±5,665 | 12.17 | 0.919 |
| SLC2A1 | 4,007±4,652 | 23,021±18,217 | 5.74 | 0.918 |
| ANXA8 | 240±740 | 3,194±3,237 | 13.30 | 0.916 |
| PTHLH | 149±307 | 3,642±5,287 | 24.41 | 0.914 |
| GBP6 | 71±203 | 2,247±2,528 | 31.33 | 0.913 |
| ABCC5 | 1,037±1,012 | 7,355±7,806 | 7.09 | 0.912 |
| SPRR1A | 36±250 | 2,333±4,852 | 63.44 | 0.912 |
| SNAI2 | 255±444 | 1,149±731 | 4.49 | 0.911 |
| SLC16A1 | 597±1,019 | 2,486±1,753 | 4.16 | 0.910 |
| TFRC | 3,415±3,639 | 18,175±19,185 | 5.32 | 0.910 |
| FOXE1 | 80±276 | 1,593±1,939 | 19.72 | 0.908 |
| BMP7 | 172±530 | 1,843±1,470 | 10.70 | 0.907 |
| ITGA6 | 1,937±3,063 | 8,650±7,228 | 4.46 | 0.906 |
| NTRK2 | 173±794 | 7,764±9,701 | 44.79 | 0.905 |
| ST6GALNAC2 | 287±316 | 1,438±978 | 5.00 | 0.904 |
| CELSR2 | 487±386 | 2,204±1,814 | 4.53 | 0.904 |
| ODZ2 | 29±146 | 1,147±1,729 | 38.99 | 0.904 |
| ADAM23 | 26±90 | 1,535±2,091 | 57.10 | 0.902 |
| GJB6 | 96±265 | 2,657±4,069 | 27.65 | 0.899 |
| ANXA8L2 | 133±347 | 1,201±1,194 | 8.99 | 0.897 |
| LGALS7 | 33±147 | 1,397±3,297 | 41.66 | 0.897 |
| S100A7 | 79±824 | 2,320±11,972 | 29.29 | 0.896 |
| RHCG | 62±554 | 2,294±5,834 | 36.71 | 0.894 |
| NRARP | 217±196 | 1,068±1,082 | 4.92 | 0.894 |
| S100A2 | 1,037±4,073 | 14,533±20,550 | 14.01 | 0.890 |
| ADH7 | 71±513 | 2,704±3,930 | 37.83 | 0.887 |
| LYPD3 | 428±839 | 3,478±4,530 | 8.12 | 0.886 |
| SPRR3 | 75±497 | 4,179±9,702 | 55.54 | 0.884 |
| COL4A5 | 312±414 | 1,956±2,391 | 6.26 | 0.884 |
| CXCR7 | 609±1,045 | 4,107±4,471 | 6.74 | 0.883 |
| C3orf58 | 458±333 | 1,881±1,718 | 4.10 | 0.883 |
| PTPRZ1 | 222±538 | 2,422±2,239 | 10.88 | 0.882 |
| GPR87 | 239±399 | 1,358±1,159 | 5.68 | 0.881 |
| RAPGEFL1 | 302±456 | 1,882±1,782 | 6.22 | 0.880 |
| UGT1A7 | 8±77 | 1,054±2,247 | 128.92 | 0.880 |
| SPRR2D | 87±428 | 2,165±4,477 | 24.63 | 0.878 |
| SPRR1B | 178±777 | 3,747±6,231 | 20.96 | 0.878 |
| KRT15 | 1,280±4,508 | 20,918±28,994 | 16.33 | 0.878 |
| PI3 | 352±4431 | 5,523±12,731 | 15.67 | 0.876 |
| SFN | 3,844±3,146 | 17,013±14,551 | 4.43 | 0.876 |
| FABP5 | 157±305 | 1,443±2,707 | 9.15 | 0.876 |
| RBP1 | 360±732 | 2,217±3,706 | 6.15 | 0.873 |
| DST | 2,550±2,332 | 10,378±8,529 | 4.07 | 0.873 |
| PITX1 | 329±586 | 2,003±2,523 | 6.08 | 0.870 |
| FAM84A | 302±428 | 1,341±1,198 | 4.44 | 0.865 |
| UPK1B | 266±1,452 | 2,995±5,424 | 11.24 | 0.864 |
| ADM | 503±728 | 2,123±2,249 | 4.22 | 0.862 |
| SOX2 | 479±830 | 43,21±4,483 | 9.02 | 0.862 |
| CLDN1 | 2,085±3,554 | 15,300±19,672 | 7.34 | 0.861 |
| MAGEA4 | 323±2,589 | 2,327±4,114 | 7.19 | 0.860 |
| NDUFA4L2 | 632±1,412 | 4,587±5,094 | 7.25 | 0.860 |
| SERPINB4 | 78±380 | 1,223±3,002 | 15.63 | 0.853 |
| FGFBP1 | 236±491 | 2,053±2,791 | 8.70 | 0.851 |
| SERPINB3 | 344±1,591 | 3,359±6,296 | 9.75 | 0.848 |
| NTS | 1,909±15,405 | 8,452±21,005 | 4.43 | 0.846 |
| FGFR2 | 547±653 | 2,244±2,092 | 4.10 | 0.845 |
| RGMA | 233±383 | 1,250±1,463 | 5.35 | 0.841 |
| ALDH3B2 | 288±450 | 1,176±1,362 | 4.08 | 0.838 |
| CYP2S1 | 568±775 | 3,034±2,938 | 5.33 | 0.833 |
| GPNMB | 6,752±7,084 | 30,334±47,047 | 4.49 | 0.831 |
| NDRG4 | 172±226 | 1,102±1,372 | 6.39 | 0.825 |
| GJB2 | 862±1,422 | 6,171±10,796 | 7.15 | 0.820 |
| ABCA13 | 257±471 | 1,296±1,327 | 5.04 | 0.812 |
| FBN2 | 154±1,446 | 1,750±3,324 | 11.34 | 0.812 |
| CRYAB | 187±291 | 1,272±4,611 | 6.80 | 0.811 |
| MMP10 | 194±1,193 | 3,002±7,273 | 15.47 | 0.808 |
| NRCAM | 221±609 | 1,241±1,578 | 5.61 | 0.806 |
| HAS3 | 1,028±1,839 | 4,158±4,225 | 4.04 | 0.804 |
| IL1RN | 449±537 | 2,017±2,468 | 4.49 | 0.804 |
| S100A8 | 1,344±8,937 | 1,1440±28,668 | 8.51 | 0.802 |
| CNTNAP2 | 164±561 | 1,116±1,722 | 6.78 | 0.798 |
| COL17A1 | 1,339±3,023 | 6,832±10,661 | 5.10 | 0.797 |
| AKR1B10 | 2,145±7,972 | 9,111±13,901 | 4.25 | 0.794 |
| WNT5A | 633±563 | 2,606±2,816 | 4.12 | 0.789 |
| CYP4F3 | 141±485 | 1,153±1,964 | 8.14 | 0.773 |
| LY6D | 214±729 | 3,033±6,896 | 14.13 | 0.765 |
| ALDH3A1 | 1,848±7,693 | 8,124±17,776 | 4.40 | 0.759 |
| IVL | 207±501 | 1,093±2,097 | 5.26 | 0.758 |
| CYP4F11 | 271±579 | 2,195±3,752 | 8.09 | 0.725 |
| GSTM2 | 458±496 | 2,044±3,044 | 4.46 | 0.703 |
| GSTM3 | 609±941 | 2,866±4,641 | 4.70 | 0.696 |
| GPC3 | 540±1,255 | 2,291±3,642 | 4.24 | 0.684 |
| KRT4 | 228±1,156 | 2,160±9,487 | 9.45 | 0.644 |
| OLFM1 | 248±296 | 1,325±2,310 | 5.33 | 0.642 |
| GSTM1 | 257±559 | 1,626±4,391 | 6.32 | 0.557 |
| C4orf7 | 87±314 | 1,896±12,269 | 21.63 | 0.530 |
ROC, receiver operating characteristic; LUSC: lung squamous cell carcinoma; LUAD, lung adenocarcinoma; AUC: area under curve.