Table 5.

GO biological process terms of the modules of QSYQ.

Modules	P value	GO terms
1	1.97E − 14	Regulation of protein metabolic process
2	1.32E − 32	DNA metabolic process
3	2.01E − 28	Regulation of cAMP metabolic process
4	4.16E − 24	G-protein coupled receptor signaling pathway
5	5.28E − 23	DNA-dependent transcription, initiation
6	3.03E − 25	Transmembrane receptor protein tyrosine kinase signaling pathway
7	4.74E − 23	Cellular lipid metabolic process
8	6.43E − 15	Apoptotic process
9	1.80E − 18	Tricarboxylic acid cycle
10	9.96E − 27	G-protein coupled receptor signaling pathway
11	1.32E − 32	Xenobiotic metabolic process
12	2.74E − 15	Toll-like receptor signaling pathway
13	5.96E − 32	Potassium ion transport
14	1.50E − 20	Lipid metabolic process
15	2.57E − 20	Xenobiotic metabolic process
16	8.66E − 12	Positive regulation of RNA metabolic process
17	2.78E − 27	Regulation of blood coagulation
18	3.33E − 14	Inflammatory response
19	1.94E − 16	Immune response-activating signal transduction
20	3.65E − 19	Apoptotic process
21	1.04E − 11	Regulation of blood coagulation
22	2.64E − 16	Nucleotide metabolic process
23	4.14E − 13	Transmembrane receptor protein tyrosine kinase signaling pathway
24	3.85E − 12	Interferon-gamma-mediated signaling pathway
25	5.59E − 07	Regulation of cellular protein metabolic process
26	4.34E − 06	RNA processing
27	1.19E − 22	Cell cycle phase transition
28	2.71E − 06	Regulation of RNA metabolic process
29	9.03E − 14	Regulation of systemic arterial blood pressure by renin-angiotensin
30	5.05E − 18	Cardiac muscle contraction
31	2.53E − 06	Regulation of RNA splicing
32	1.13E − 09	Carbohydrate metabolic process
33	9.21E − 14	Insulin receptor signaling pathway
34	3.77E − 08	Lipid catabolic process
35	2.50E − 22	Cellular amino acid catabolic process
36	1.93E − 17	Regulation of cell cycle
37	2.42E − 14	Lipid metabolic process
38	3.52E − 17	mRNA metabolic process
39	2.31E − 06	Execution phase of apoptosis
40	1.16E − 15	Toll-like receptor signaling pathway
41	3.70E − 11	RNA biosynthetic process
42	3.65E − 12	Cell cycle phase
43	2.80E − 12	Cellular amino acid metabolic process
44	6.84E − 05	Regulation of cell proliferation
45	1.17E − 07	Inflammatory response
46	4.51E − 09	RNA biosynthetic process
47	3.74E − 11	Regulation of interleukin-1 secretion
48	1.49E − 13	DNA repair
49	1.67E − 18	Insulin receptor signaling pathway
50	3.18E − 06	Negative regulation of RNA metabolic process
51	1.24E − 04	Transport
52	8.34E − 14	Regulation of transforming growth factor beta receptor signaling pathway
53	4.47E − 06	Xenobiotic metabolic process
54	1.16E − 08	Negative regulation of inflammatory response
55	1.37E − 07	Positive regulation of RNA metabolic process
56	5.56E − 07	Transmission of nerve impulse
57	5.79E − 12	Mitotic cell cycle
58	6.69E − 06	Negative regulation of protein metabolic process
59	2.66E − 12	Regulation of apoptotic signaling pathway
60	2.00E − 09	Regulation of apoptotic signaling pathway
61	2.47E − 11	NIK/NF-kappaB cascade
62	4.69E − 15	Vascular endothelial growth factor receptor signaling pathway
63	1.98E − 06	DNA metabolic process
64	2.04E − 04	Chromatin organization
65	1.11E − 05	DNA packaging
66	9.39E − 07	Inflammatory response
67	3.22E − 09	Xenobiotic metabolic process
68	8.09E − 12	Insulin receptor signaling pathway
69	8.52E − 04	DNA-dependent transcription, initiation
70	1.56E − 05	DNA replication
71	5.51E − 07	Toll-like receptor signaling pathway
72	2.16E − 08	Copper ion import
73	2.90E − 08	Transmission of nerve impulse
74	4.63E − 07	Regulation of blood coagulation
76	6.90E − 04	Alanine catabolic process
77	6.76E − 05	RNA biosynthetic process
78	7.60E − 04	Lipid metabolic process
79	2.86E − 05	TRIF-dependent toll-like receptor signaling pathway
81	4.18E − 05	Regulation of type I interferon production
83	5.21E − 03	Cellular lipid metabolic process
84	1.27E − 11	Neural crest cell migration
85	2.10E − 03	AMP catabolic process

Notes. P value is the probability of obtaining the observed effect under the null hypothesis; a very small P value indicates that the observed effect is very unlikely to have arisen purely by chance.