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. 2015 Aug 24;2015:965710. doi: 10.1155/2015/965710

Table 1.

Clinical and laboratory findings in prairie dogs intranasally challenged (8 × 103 pfu) with West African (WA) MPXV.

Sacrifice day p.i. Prairie dog # Max. # of cutaneous lesions observed OPXV antibodies detected Neutralizing antibodies detected Clinical symptoms Gross pathology Poxvirus IHC Viable virus (#positive/#tested)
2 PD9 0 Neg. Neg. N.O. N.O. N.E. 0/28
PD10 0 Neg. Neg. N.O. N.O. N.E. 0/28

4 PD11 0 Neg. Neg. N.O. N.O. N.O. 0/28
PD12 0 Neg. Neg. N.O. N.O. N.O. 0/28

6 PD13 0 Neg. Neg. N.O. N.O. N.O. 10/28
PD14 0 Neg. Neg. N.O. N.O. N.O. 10/28

9 PD15 0 Neg. + R.D. Pale kidneys LN, epithelial, dermis 15/28
PD16 0 Neg. Neg. R.D. N.O. LN, spleen 16/28

12 PD17 20 + N.E. Inappetence Lymphadenopathy, inflamed oviducts Buccal/caudal pharyngeal mucosa, uterus, mesenchymal cells (mononuclear inflammatory cells/reactive fibroblasts) 21/28
PD18 12 + N.E. Inappetence Lymphadenopathy Epithelial, tonsil, fibroblasts 10/28
PD21 3 N.E. N.E. Inappetence, nasal discharge Hemorrhage of uterine horns and adipose tissue associated with the round ligament, hyperemic areas associated with the ovaries and inflamed oviducts, and hepatomegaly All tissues positive for antigen except for brain 26/28

17 PD19 >20 + + Inappetence Lymphadenopathy, hemorrhagic foci in the adipose tissue associated with lymph nodes and multiple, mild foci of serosal hemorrhage on the lungs Peritesticular adipose tissue 14/28

24 PD20 5 + N.E. N.O. N.O. N.E. 0/28
PD22 20 + N.E. N.O. Pericarditis N.E. 1/28

Groups of prairie dogs were serially sacrificed (days 2, 4, 6, 9, 12, 17, and 24) following challenge (n = 14). Animals were observed for clinical symptoms, antibody production, and lesion presentation. Gross observations were recorded and postmortem samples were evaluated for presence of virus and histopathological changes. R.D.: respiratory depression under anesthesia; N.O.: nothing observed; N.E. not examined.

†: unscheduled death.