FIGURE 2.

Dopamine release in the hippocampus is critical for long-term retention of episodic memories in rodents. In the event arena, injection of the D1/D5 receptor antagonist (SCH23390) into the hippocampus prior to encoding did not affect episodic memory when a retrieval test was given after a 30-min delay. However, a strong negative effect was seen after 24 h. At this time point, animals who had received saline (NaCl) injections continued to perform adequately, but those who had received SCH23390 injections performed at chance levels. Reprinted from Bethus et al. (2010) with permission from the Society for Neuroscience. *p < 0.05, **p < 0.01, ns, means non-significant.