Figure 2.

Spatial distribution of titin frameshift and non-sense mutations in Finnish dilated cardiomyopathy cohort. Titin is linearly depicted with its 152 Immunoglobulin-like domains in green and 132 fibronectin type III domains in purple. TTN mutations are shown as lollipops. Depicted are non-sense (red) and frameshift (green) mutations in subjects with dilated cardiomyopathy. Variants are shown relative to the titin Uniprot Sequence identifier Q8WZ42. The dashed lines below the protein schematic indicate the location of variants within the sarcomere.