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Non-rooted tree of Class I protozoan and human PDEs. The catalytic domains of many protozoan PDEs, including T. brucei (in red), are as closely related to the human PDEs (in blue) as these are among themselves. Hs, Homo sapiens; Pf, Plasmodium falciparum; Ca, Candida albicans; Tp, Theileria parva; Gl, Giardia lamblia; Ch, Chilomastix hominis; Ec, Encephalitozoon cuniculi; Dd, Dictyostelium discoideum. Figure courtesy of Professor T. Seebeck, University of Bern, Switzerland.
