Table 1:
Body of Evidence Examined According to Study Design
| Study Design | Number of Eligible Studies | |
|---|---|---|
| RCTs | ||
| Systematic review of RCTs | 1 | |
| Large RCT | 10a | |
| Small RCT | 3 | |
| Observational Studies | ||
| Systematic review of non-RCTs with contemporaneous controls | 3 | |
| Non-RCT with contemporaneous controls | 11 | |
| Systematic review of non-RCTs with historical controls | 6 | |
| Non-RCT with historical controls | 3 | |
| Database, registry, or cross-sectional study | 3 | |
| Case series | ||
| Retrospective review, modelling | 14 | |
| Studies presented at international conference | ||
| Expert opinion | ||
| Total | 54 | |
Abbreviation: RCT, randomized controlled trial.
a
Two reports were from the same study. Includes one cluster RCT.