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. 2015 Sep;22(9):411–416. doi: 10.1101/lm.037291.114

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© 2015 Kim et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — A metaplasticity model of stress effects on hippocampal synaptic plasticity. Based on the metaplasticity hypothesis, stress and glucocorticoids have been proposed to shift the dynamic range of depression and potentiation (represented by the modification threshold, θ_m) to the right such that subsequent synaptic plasticity favors LTD over LTP. The shaded area represents the physiological range of θ_m associated with the varying endogenous state (e.g., circadian rhythms, age, sex) of the animal. From Kim and Yoon (1998).