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MECIII input to hippocampal CA1 is crucial for trace fear conditioning. (A) Diagram of entorhinal hippocampal circuits. Stellate Ocean cells (purple) in ECII project to the DG, CA3, and CA2 region, whereas ECIII cells (orange) directly project to the CA1 region. (B) Possible mechanisms. Tone-induced MECIII persistent activity may activate the CA1 pyramidal cells to bridge the temporal gap during the trace period of memory task.
