Fig. 2.

The superimposition of the FFA1 crystal structure and homology models base on the backbone of the helices in the extracellular side. The crystal structure, rhodopsin, β₂ adrenergic and PAR₁-based homology models are in yellow, cyan, pink and grey colour, respectively. Residues predicted to be important for ligand coordination based on mutagenesis and residue K62^2.60, representing the possible anchoring point for allosteric ligands are shown in stick-like representation. The green arrows indicate the large movement of helices 3, 4 and 5 in the FFA1 crystal structure compared to the homology models