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. 2015 Sep 7;15:16. doi: 10.1186/s12900-015-0044-2

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© Tikhonova and Poerio. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The ligand binding mode at the FFA1 crystal structure and homology models. a: the binding model of TAK-875, the ago-allosteric ligand in the FFA1 crystal structure, the ligand is pointed between helices 3 and 4 (mode 1 in the text). b: The binding mode of GW9508, the high potency agonist in the previous rhodopsin-based homology model of FFA1. The model was obtained from ref 12. c: The binding mode of TAK-875 in the PAR₁-based model of FFA1. Hydrogen bonds are in black