Table 6.

Upper limit of parasite positivity rates (PPRs) which could be observed on day 3

Variable	AL		ASAQ-FDC		DP
	Day 3 PPR (95 % CI)	Maximum predicted riska	Day 3 PPR (95 % CI)	Maximum predicted riska	Day 3 PPR (95 % CI)	Maximum predicted riska
Age category
<1 year	0.79 (0.00–1.67)	6.50	0.67 (0.00–2.00)	7.69	0.68 (0.00–1.45)	6.00
1 to <5 years	0.54 (0.28–0.79)	4.30	0.70 (0.19–1.21)	6.00	0.83 (0.00–1.65)	6.35
5 to <12 years	0.69 (0.26–1.11)	6.00	0.32 (0.00–0.76)	4.11	0.70 (0.07–1.34)	6.00
≥12 years	0.49 (0.11–0.88)	4.76	0.13 (0.00–0.40)	4.00	0.48 (0.00–1.06)	5.66
Transmission
High	0.20 (0.03–0.37)	4.00	0.27 (0.06–0.48)	4.00	0.05 (0.00–0.15)	2.00
Low/moderate	0.79 (0.43–1.15)	6.00	0.65 (0.09–1.22)	6.00	1.28 (0.27–2.29)	8.00
Parasitaemia (x 1,000 parasites/μl)
<10	0.39 (0.18–0.60)	4.00	0.43 (0.00–0.91)	4.92	0.87 (0.00–1.81)	7.02
10 to <50	0.58 (0.30–0.86)	4.62	0.35 (0.00–0.72)	4.00	0.54 (0.01–1.08)	5.77
50 to <100	0.81 (0.32–1.30)	6.00	1.01 (0.20–1.83)	7.02	0.86 (0.00–1.85)	7.14
≥100	1.04 (0.35–1.74)	6.67	1.12 (0.00–2.25)	8.00	1.15 (0.13–2.17)	8.00
Study sample size
<50	1.02 (0.12–1.92)	10.34	0.78 (0.00–2.00)	10.71	0.00 (0.00–7.71)	20.68
50 to <100	0.72 (0.30–1.13)	6.00	0.55 (0.00–1.53)	6.00	0.25 (0.00–0.50)	4.00
100 to <200	0.90 (0.34–1.45)	4.62	0.88 (0.08–1.68)	5.00	1.43 (0.00–3.03)	7.01
≥200	0.25 (0.05–0.45)	1.75	0.18 (0.02–0.35)	1.50	0.70 (0.00–1.73)	4.00
Overall	0.58 (0.34–0.82)	4.41	0.54 (0.14–0.94)	5.08	0.77 (0.11–1.42)	6.00

^aThe maximum predicted risk is the day 3 PPR which could be observed assuming the worst case day 3 PPR, that is, the upper limit of day 3 PPR 95 % CI. For calculating the maximum predicted risk for age, transmission and parasitaemia, a minimum study sample size of 50 in a study was assumed. AL, artemether-lumefantrine; ASAQ-FDC, fixed dose combination; DP, dihydroartemisinin-piperaquine; PPR, parasite positivity rate